Dr Prerna Kohli

Ayurvedic Nutrition for Mind and Body: Six Supplements and the Evidence Behind Them

Wellbeing & Mind–Body · Dr. Prerna Kohli

Ayurvedic Nutrition for Mind and Body: Six Supplements and the Evidence Behind Them

The herbs and spices of the Indian kitchen have been used for wellbeing for centuries — and researchers are now testing several in randomised controlled trials. The picture is encouraging but nuanced: some have solid support, others are still being understood. Here is an honest look at six, for mind and body.

Quick answer

Ayurveda is one of the world's oldest systems of medicine, recognised and regulated in India through the Ministry of AYUSH. Much as modern "nutritional psychiatry" studies how food shapes mood, Ayurvedic nutrition has long held that what we eat nourishes both body and mind. Several traditional supplements — such as ashwagandha, tulsi, and turmeric — are now being tested in clinical research, and for some the evidence is genuinely promising, particularly for stress, sleep, mood, and inflammation. They are best seen as one small part of a healthy life, alongside — never instead of — proper medical and psychological care.

PK

Who's writing this. Dr. Prerna Kohli is a clinical psychologist with a PhD and M.Phil in Clinical Psychology from Aligarh Muslim University and over 30 years in practice — a TEDx speaker, published author, and recipient of the "100 Women Achievers of India" award from the President of India. She writes here on the mind–body connection and the growing research on nutrition and mental wellbeing. This article reviews published research; it is not medical or Ayurvedic prescribing — for personal advice, please consult your doctor or a qualified Ayurvedic physician (vaidya).

What is new is not the herbs, but the testing: many are now being studied in the same kind of randomised controlled trials used for modern medicines. Below, the six are grouped by what they are traditionally used for, beginning with those closest to the mind.

The evidence at a glance

Best-studied
Ashwagandha & curcumin (turmeric) — multiple trials and meta-analyses for stress, sleep, and mood.
Supportive
Tulsi (stress) and Triphala (digestion) — favourable human evidence and good safety records.
Mixed / unproven
Karela for blood sugar — inconclusive; enjoy as a food, not a treatment.

Sources: peer-reviewed systematic reviews and meta-analyses cited in full below (PMC, NIH Office of Dietary Supplements, Frontiers, JAPS).

For the mind: stress, sleep, and mood

Ashwagandha Withania somnifera

Traditionally: A prized Ayurvedic rasayana (rejuvenative) and adaptogen — a herb thought to help the body cope with stress.

What research suggests: Among the best-studied Ayurvedic herbs. Multiple randomised controlled trials and systematic reviews suggest ashwagandha root extract can meaningfully reduce perceived stress and anxiety, lower the stress hormone cortisol, and improve sleep quality.[1][2]

Studied amounts: commonly around 250–600 mg/day of standardised root extract in trials.
Caution: generally well tolerated, but not advised in pregnancy, and it may interact with thyroid, sedative, or immune medication — check with your doctor.

Tulsi (Holy Basil) Ocimum sanctum / tenuiflorum

Traditionally: Revered in Ayurveda as "the elixir of life" and grown in countless Indian homes; used as an adaptogen for resilience and calm.

What research suggests: A systematic review of around two dozen human studies concluded the evidence for Tulsi as an adaptogen is favourable, with several controlled trials reporting reductions in stress and anxiety.[3] You can also simply grow it and chew the fresh leaves.

Studied amounts: roughly 500–1,200 mg/day of leaf extract in trials.
Caution: well tolerated; if you take blood-thinning or blood-sugar medication, mention it to your doctor.

Turmeric (Haldi) — curcumin Curcuma longa

Traditionally: The golden spice of Indian cooking, long valued as an anti-inflammatory and healing agent.

What research suggests: Its active compound, curcumin, is a genuine bridge between body and mind: meta-analyses of clinical trials suggest it can ease symptoms of depression and anxiety, alongside its well-studied anti-inflammatory and antioxidant effects.[4] Curcumin is poorly absorbed alone, which is why it is traditionally paired with black pepper, whose piperine markedly improves its uptake.

Studied amounts: as a supplement, often 500–1,500 mg/day of curcumin (far more concentrated than culinary haldi).
Caution: high-dose supplements can thin the blood and may not suit those with gallbladder issues or on anticoagulants.

For the body: digestion and metabolism

Triphala Amalaki, Bibhitaki & Haritaki

Traditionally: A classic blend of three fruits, used for centuries to support the lower digestive tract and gentle, regular cleansing.

What research suggests: Clinical and review evidence supports Triphala's traditional digestive role — trials report improved bowel regularity and a healthier balance of gut bacteria — along with antioxidant and anti-inflammatory activity and a good safety record.[5]

Studied amounts: commonly around 500–2,000 mg/day.
Caution: may have a mild laxative effect; start low.

Trikatu Black pepper, long pepper & ginger

Traditionally: A warming three-spice formula used to kindle digestion in the upper digestive tract — a companion to Triphala's work lower down.

What research suggests: Evidence-based reviews describe Trikatu's antimicrobial, antioxidant, and metabolic actions — and its peppers contain piperine, well documented to boost the absorption of other compounds such as curcumin.[6]

Studied amounts: traditionally a few hundred milligrams with meals.
Caution: being warming and pungent, it may aggravate acidity in some people.

Karela (Bitter Melon) Momordica charantia

Traditionally: A familiar, intensely bitter vegetable of the subcontinent, long used to support healthy blood sugar.

What research suggests: Here the evidence is genuinely mixed. Some randomised trials show a modest glucose-lowering effect, but a systematic review and meta-analysis concluded that overall a clear benefit could not be established — though it appears generally safe.[7] Best thought of as a wholesome vegetable to enjoy fresh, not a substitute for medical care.

Studied amounts: as a fresh vegetable, or standardised extracts in trials.
Caution: if you have diabetes, treat karela as a complement to — never a replacement for — prescribed treatment. Because it can lower blood sugar, combining it with glucose-lowering medication may risk hypoglycaemia, so coordinate with your doctor. Not advised in pregnancy.

Two safety essentials. First, supplements are not a cure and work alongside — never instead of — good medical and psychological care; always check with your doctor before starting, especially if you are pregnant, breastfeeding, on medication, or managing a health condition. Second, quality varies: some Ayurvedic products have been found to contain heavy metals or contaminants, so choose reputable, quality-tested brands, ideally on the advice of a qualified vaidya.

The most reassuring finding across this research is also the most Ayurvedic: body and mind are not separate. The same turmeric studied for inflammation is studied for mood; the same ashwagandha that lowers cortisol also improves sleep. Nourishing one tends to nourish the other.

If stress, sleep, or mood are weighing on you

Supplements are only one small piece. If stress, poor sleep, or low mood are weighing on you, support for the rest is here whenever you need it.

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Frequently asked questions

Are Ayurvedic supplements safe?

Many are generally well tolerated, and Ayurveda is recognised and regulated in India through the Ministry of AYUSH. But "natural" does not automatically mean risk-free: supplements can interact with medication, are not advised in some conditions or in pregnancy, and product quality varies — some have been found to contain contaminants. The safest approach is to choose reputable, quality-tested products and check with your doctor or a qualified Ayurvedic physician before starting, especially if you take medication.

Can ashwagandha really help with stress and sleep?

The evidence is among the strongest for any Ayurvedic herb. Multiple randomised controlled trials and systematic reviews suggest ashwagandha root extract can reduce perceived stress and anxiety, lower cortisol, and improve sleep quality. That said, studies vary in size and quality, it is not a cure, and it may interact with thyroid, sedative, or immune medication and is not advised in pregnancy. Treat it as a possible support, and check with your doctor first.

Does turmeric or curcumin help with depression?

Meta-analyses of clinical trials suggest curcumin — turmeric's active compound — can ease symptoms of depression and anxiety, alongside its anti-inflammatory effects. This is promising, but it is not a substitute for treatment of depression, and the amounts studied are far more concentrated than culinary haldi. If you are experiencing depression, please seek proper care; curcumin might complement it, but should not replace therapy or medication. Discuss it with your doctor, particularly if you are on blood thinners.

Can these supplements replace my medication or therapy?

No. This is the most important point: supplements are best seen as one small part of a healthy life, working alongside — never instead of — good medical and psychological care. Stopping prescribed treatment in favour of supplements can be dangerous. If a condition like depression, anxiety, or diabetes is involved, keep your medical care central and treat any supplement as a possible complement only, discussed with your doctor.

Should I check with a doctor before taking Ayurvedic supplements?

Yes — especially if you are pregnant or breastfeeding, take any medication, or manage a health condition. Several of these herbs can interact with medicines (for the thyroid, blood clotting, blood sugar, or the immune system) or are unsuitable in certain situations. A qualified Ayurvedic physician (vaidya) or your doctor can advise on what is appropriate and safe for you personally, which general information like this cannot.

Why is turmeric taken with black pepper?

Because curcumin, turmeric's active compound, is poorly absorbed on its own. Black pepper contains piperine, which markedly improves curcumin's uptake by the body — a pairing traditional Indian cooking arrived at long before the science explained it. This is also why the Ayurvedic spice blend Trikatu, which contains pepper, is noted for boosting the absorption of other compounds. A pinch of pepper with your haldi is a small, time-honoured trick.

Are Ayurvedic supplements regulated?

In India, Ayurveda is recognised and regulated through the Ministry of AYUSH, and licensed products must meet certain standards. However, regulation and quality control vary between products and markets, and independent testing has sometimes found contaminants in a minority of products. This is why choosing reputable, quality-tested brands — ideally on a qualified practitioner's advice — matters, rather than assuming every product on the shelf is equally safe or standardised.

Can I take these if I'm pregnant or breastfeeding?

Several of these herbs — including ashwagandha and karela — are specifically not advised in pregnancy, and safety data during breastfeeding is often limited. As a rule, do not start herbal supplements while pregnant or breastfeeding without clear guidance from your doctor or a qualified Ayurvedic physician. Enjoying culinary amounts of common spices in food is different from taking concentrated supplement doses, which is where the caution mainly applies.

Does karela (bitter melon) lower blood sugar?

The evidence is genuinely mixed. Some randomised trials show a modest glucose-lowering effect, but a systematic review and meta-analysis found no clear, established benefit overall. It appears generally safe as a food, and is best enjoyed as a wholesome vegetable rather than relied on as a treatment. Crucially, if you have diabetes, never replace prescribed treatment with karela — and because it can lower blood sugar, combining it with medication may risk hypoglycaemia, so coordinate with your doctor.

How do I choose a good-quality Ayurvedic supplement?

Look for reputable manufacturers with proper licensing and, ideally, independent testing for purity and heavy metals, since contamination has been documented in a minority of products. Standardised extracts (with the active content stated) are more consistent than generic powders. Avoid unlabelled or unverified products, and be wary of exaggerated cure claims. Best of all, choose with the guidance of a qualified Ayurvedic physician or your doctor, who can point you toward trustworthy options for your needs.

Can supplements help my mental health on their own?

They are, at most, a small supporting piece — not a standalone answer. Some herbs like ashwagandha and curcumin show promise for stress, sleep, and mood in research, but mental health rests far more on the foundations: sleep, connection, movement, managing stress, and, where needed, therapy and medical care. If stress, poor sleep, or low mood are weighing on you, please prioritise proper support. A supplement might complement that, but it cannot replace it.

Used wisely and alongside proper care, these traditional foods and herbs can be a small, nourishing part of looking after mind and body. You may also enjoy reading about managing everyday stress, meditation for calm, chanting for happiness, and how anxiety and low mood are understood and treated. If you would like support, a clinical psychologist in Gurugram can help.

Sources: [1] Ashwagandha for stress and anxiety, systematic review and meta-analysis (BJPsych Open / PMC). [2] Ashwagandha health-professional fact sheet (NIH Office of Dietary Supplements). [3] The clinical efficacy and safety of Tulsi in humans: a systematic review (PMC). [4] Curcumin for depression and anxiety, systematic review and meta-analysis (Frontiers in Pharmacology / PMC). [5] Triphala — pharmacology and clinical potential review (Journal of Applied Pharmaceutical Science, 2025). [6] Trikatu — evidence-based review incl. piperine and bioavailability (JAPS, 2025). [7] Metabolic effects of Momordica charantia, systematic review and meta-analysis (Frontiers in Nutrition / PMC).

PK

Dr. Prerna Kohli

Clinical Psychologist · PhD & M.Phil, Clinical Psychology (Aligarh Muslim University)

Dr. Prerna Kohli is a clinical psychologist with more than three decades of experience in private practice in Gurugram, working with individuals and families across India and the Indian diaspora, with a particular interest in stress, sleep, and the mind–body connection. A TEDx speaker and published author, she was honoured with the "100 Women Achievers of India" award (2016) by the President of India, and is recognised as a notable subject on Wikipedia and Wikidata.

This article is for general information and is not a substitute for personalised medical, psychological, or Ayurvedic advice. Always consult a qualified professional before starting any supplement.